Recombinant polypeptide construct comprising Plasmodium falciparum circumsporozoite protein HLA class I restricted T-cell epitopes

摘要

The invention relates to a recombinant polypeptide construct comprising epitopes from Plasmodium falciparum protein circumsporozoite protein (CSP). The epitopes contain HLA class I binding motifs and stimulate an anti-malaria CD8+ T-cell response. The polypeptides can be incorporated into immunogenic formulations against malaria. Additionally, the antigens are useful for facilitating evaluation of immunogenicity of candidate malaria vaccines.

主权项

1. A recombinant polypeptide construct comprising one or more Plasmodium falciparum circumsporozoite protein T-cell epitopes, wherein said epitopes contain the amino acid sequences selected from the group consisting of SEQ ID No. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 and wherein said epitopes are linked directly or via polypeptide spacer sequences that do not contain a T-cell epitope.