Methods of Using Selective Chemotherapeutic Agents for Targeting Tumor Cells

摘要

A method for treating cancer tumors, particularly ovarian cancer tumors, is described, where fused cyclic pyrimidine having a cancer treating ability is selectively delivered to an FR expressing cancerous tumor.

主权项

1. A method for inhibiting GARFTase in cancerous tumors of a patient comprising:
a) providing a fused cyclic pyrimidine having the chemical formula:where n=5 or 6;
b) selectively delivering the fused cyclic primidine alone to endometrial, kidney, lung, mesothelioma, and brain cancerous tumors, where the fused cyclic pyrimidine due to the use of CH2 chains, where n=5 or 6, targets primarily FR-expressing cancerous tumors; and c) passing of the fused cyclic pyrimidine into said cancerous tumors where the fused cyclic pyrimidine itself acts as a cancer treating agent and inhibits GARFTase within the tumors.