| 发明名称 |
BROAD SPECTRUM PRO-QUORUM-SENSING MOLECULES AS INHIBITORS OF VIRULENCE IN VIBRIOS |
| 摘要 |
Using a whole-cell high-throughput screen, eleven molecules were identified that activate V. cholerae quorum sensing (QS). Eight molecules are receptor agonists and three molecules are antagonists of LuxO, the central NtrC-type response regulator that controls the global V. cholerae QS cascade. Pro-QS molecules are used for the development of novel anti-infectives. |
| 申请公布号 |
US2015126474(A1) |
申请公布日期 |
2015.05.07 |
| 申请号 |
US201314381432 |
申请日期 |
2013.02.20 |
| 申请人 |
THE TRUSTEES OF PRINCETON UNIVERSITY |
发明人 |
Bassler Bonnie L.;Ng Wai-Leung;Perez Lark J.;Cong Jianping;Semmelhack Martin F. |
| 分类号 |
C07D253/075;A01N43/707;A01N55/00;C07F7/10 |
主分类号 |
C07D253/075 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A compound from the group consisting of: |
| 地址 |
Princeton NJ US |
