发明名称 |
AN INDUSTRIALLY APPLICABLE PROCESS FOR PREPARING HIGH PURITY ACLIDINIUM BROMIDE |
摘要 |
<p>An efficient and industrially applicable process for preparing aclidinium bromide of formula I, comprising the following steps a) preparation of the quinuclidinyl ester by transestenfication of methyl di(2-thienly)giycolate with R-(-)-3-quinuclidinol in the presence of a sterically hindered base in an inert solvent; b) isolation of the quinuclidinyl ester; and c) quaternization of the quinuclidinyl ester by 3-phenoxypropyl bromide in a suitable solvent.</p> |
申请公布号 |
WO2015062560(A1) |
申请公布日期 |
2015.05.07 |
申请号 |
WO2014CZ00123 |
申请日期 |
2014.10.29 |
申请人 |
ZENTIVA, K.S. |
发明人 |
CERNA, IGOR;HAJICEK JOSEF |
分类号 |
C07D453/02 |
主分类号 |
C07D453/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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