| 发明名称 |
COMPOSITIONS AND METHODS FOR TREATING HEMATOLOGIC CANCERS TARGETING THE SIRP - CD47 INTERACTION |
| 摘要 |
The invention relates to modulating the SIRP±-CD47 interaction in order to treat haematological cancer and compounds therefor. In some embodiments, there is provided methods and uses of SIRP± polypeptides, fragments and fusion proteins for treating haematological cancer, preferably human acute myeloid leukemia. |
| 申请公布号 |
EP2429574(B1) |
申请公布日期 |
2015.05.06 |
| 申请号 |
EP20100774475 |
申请日期 |
2010.05.14 |
| 申请人 |
UNIVERSITY HEALTH NETWORK;THE HOSPITAL FOR SICK CHILDREN |
发明人 |
WANG, C. Y., JEAN;DICK, JOHN;DANSKA, JAYNE;JIN, LIQING;THEOCHARIDES, ALEXANDRE;RAJAKUMAR, SUJEETHA |
| 分类号 |
A61K38/45;A61K38/16;A61K47/48;A61P35/00;A61P35/02;C12Q1/68 |
主分类号 |
A61K38/45 |
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