发明名称 |
TWO-PHOTON FLUORESCENT PROBE USING NAPHTHALENE AS MATRIX AND PREPARATION METHOD AND USE THEREOF |
摘要 |
<p>The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X 1 , X 2 , X 3 and X 4 ; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample.</p> |
申请公布号 |
EP2778161(B1) |
申请公布日期 |
2015.05.06 |
申请号 |
EP20120870663 |
申请日期 |
2012.03.05 |
申请人 |
DALIAN UNIVERSITY OF TECHNOLOGY;DALIAN CHROMAS BIOSCIENCE CO., LTD. |
发明人 |
PENG, XIAOJUN;ZHANG, HUA;FAN, JIANGLI;WANG, JINGYUN |
分类号 |
C07D401/12;C07D403/12;C07D471/04;C09K11/06;C12Q1/02 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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