DUAL IONIC PH-SENSITIVE COPOLYMER AND USE THEREOF

摘要

The present invention relates to a dual ionic pH-sensitive copolymer which is micellized/demicellized according to a change in pH, a method of manufacturing the same, and a micelle including the same. The dual ionic pH-sensitive copolymer according to the present invention can be micellized/demicellized by regulating pH. Using pH-sensitivity, treatment drugs, contrast agents, and molecular image labelling agents can be inserted into the micelle generated from the block copolymer, and the resultant micelle can be injected into the body so that drugs can be selectively released into the affected area having a low pH. Therefore, the copolymer according to the present invention can be employed as a drug carrier for diagnosis and/or treatment of diseases.