发明名称 |
NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-D]PYRIMIDINES AS LRRK2 INHIBITORS |
摘要 |
The present invention provides novel 4,5-disubstituted-7H-pyrrolo[2,3-d]pyrimidine derivatives of Formula I, and the pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4 and R5 are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy. |
申请公布号 |
EP2867236(A1) |
申请公布日期 |
2015.05.06 |
申请号 |
EP20130752678 |
申请日期 |
2013.06.19 |
申请人 |
PFIZER INC. |
发明人 |
GALATSIS, Paul;HAYWARD, Matthew Merrill;HENDERSON, Jaclyn;KORMOS, Bethany Lyn;KURUMBAIL, Ravi G;STEPAN, Antonia Friederike;VERHOEST, Patrick Robert;WAGER, Travis T.;ZHANG, Lei |
分类号 |
C07D487/04;C07D519/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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