发明名称 |
Sequência polinucleotídica, composição farmacêutica, vacina, vetor de expressão em mamíferos, vacina, método para a deteccção de infecção por bordetella, e, kit diagnóstico para a detecção de presença ou ausência de anticorpos contra bordetella |
摘要 |
<p>The present invention is related with the field of Biomedicine. It comprises the engineering of the Pertactin protein (Prn) and using it as part of bacterial vaccines, and more precisely, as part of acellular vaccines against Bordetella pertusis. The engineered Prn molecules comprise on their structure polimorfisms from different B. pertussis strains, and induce immune responses with protective capacity and opsonophagocytic activity when assayed as vaccines, higher than that generated by other pre-existing vaccines. The engineered Prn variants of the present invention are applicable in human and veterinary medicine.</p> |
申请公布号 |
BRPI0817898(A2) |
申请公布日期 |
2015.05.05 |
申请号 |
BR2008PI17898 |
申请日期 |
2008.10.17 |
申请人 |
CENTRO DE INGENIÉRIA GENÉTICA Y BIOTECNOLOGIA |
发明人 |
DIÓGENES QUINTANA VÁZQUEZ;TAMARA MENENDEZ MEDINA;ANABEL ÁLVAREZ ACOSTA;YOELIS CRUZ LEAL;GERARDO HENRIQUE GUILLEN NIETO |
分类号 |
A61K39/10;A61P31/04;C07K14/235 |
主分类号 |
A61K39/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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