发明名称 |
Anvendelse af kobber og glutamat i cellekulturer til fremstilling af polypeptider |
摘要 |
<p>An improved system for large scale production of polypeptides in cell culture is provided. In accordance with the present invention, cells expressing a polypeptide of interest are grown in media that contain copper, glutamate or both. The use of such a system allows production of polypeptides in which misfolding and/or aggregation are reduced, and in which total glycosylation is increased. Polypeptides expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical, agricultural or other commercial compositions.</p> |
申请公布号 |
DK2115126(T3) |
申请公布日期 |
2015.05.04 |
申请号 |
DK20080731084T |
申请日期 |
2008.02.29 |
申请人 |
WYETH LLC |
发明人 |
DRAPEAU, DENIS;HILLER, GREGORY;SNOW, JESSICA;LUAN, YEN-TUNG |
分类号 |
C12N5/00;C07K14/435;C12P21/02 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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