发明名称 |
Fremgangsmåde til fremstilling af Ramipril |
摘要 |
<p>Enantio-specific synthesis of optically pure (2S)-acetylamino-3-(2-oxo-cyclopentyl)- propionic acid (I) comprising converting enantiomeric mixture of (1 -4C alkyl)-2- acetylamino-3-(2-oxocyclopentyl) propionoate (II) (+ and -) under the influence of an Alkaline serine endopeptidase is disclosed. The invention further describes use of optically pure (2S)-acetylamino-3-(2-oxocyclopentyl)-propionic acid (I) formed by the process of present invention, in the preparation of Ramipril.</p> |
申请公布号 |
DK2598479(T3) |
申请公布日期 |
2015.05.04 |
申请号 |
DK20110840625T |
申请日期 |
2011.04.05 |
申请人 |
AARTI HEALTHCARE LIMITED |
发明人 |
DESAI, PARIMAL;SALVI, NARENDRA;PATRAVALE, BHARATKUMAR |
分类号 |
C07D209/52;C07C231/18;C07C231/20;C07C233/47 |
主分类号 |
C07D209/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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