发明名称 6-AMINOISOQUINOLINE COMPOUNDS
摘要 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
申请公布号 US2015119419(A1) 申请公布日期 2015.04.30
申请号 US201414583439 申请日期 2014.12.26
申请人 Aerie Pharmaceuticals, Inc. 发明人 deLong Mitchell A.;Royalty Susan M.;Sturdivant Jill Marie;Heintzelman Geoffrey Richard
分类号 C07D217/04;C07D401/12 主分类号 C07D217/04
代理机构 代理人
主权项 1. A compound according to Formula II: wherein R1 and R2 are, independently, hydrogen, hydroxyl, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, amino, nitro, cyano, C1-C4 carbonyl, C1-C4 carbonylamino, C1-C4 alkoxy, C1-C4 sulfonyl, C1-C4 sulfonylamino, C1-C4 thioalkyl or C1-C4 carboxyl; wherein R4 is hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, amino, cyano, cycloalkyl, heterocycloalkyl, aryl, C1-C4 alkyl aryl, heteroaryl, C1-C4 alkyl heteroaryl, carbonyl, carbonylamino, thioalkyl, sulfonyl, sulfonylamino, acyl, or carboxyl; and wherein B is a chain containing from 0 to 3 member atoms, X represents n independently chosen member atoms which together form a ring structure and n is an integer from about 0 to about 5.
地址 Research Triangle Park NC US