| 主权项 |
1. A method for screening for or diagnosing the likelihood of developing Alzheimer's disease, comprising:
(a) providing a tissue sample which has been extracted from a human body of an individual to be tested wherein the tissue sample contains at least a locus containing the clusterin (CLU), also known as APOJ, gene on chromosome 8, the PICALM gene on chromosome 11; complement receptor 1 gene (CR1) on chromosome 1; the bridging integrator/gene (BIN1) on chromosome 2; the ATP-binding cassette, sub family A, member 7 (ABCA7) on chromosome 19 and the membrane-spanning 4A (MS4A) gene cluster on chromosome 11; (b) examining said locus in order to identify whether SNP rs11136000 is present in the clusterin locus; rs3851179 is present in the PICALM locus; rs1408077, rs6701713 or rs3818361 is present in the CR1 locus; rs7561528 or rs744373 is present in the BIN1 locus; rs3764650 is present in the ABCA7 locus; and rs670139, rs610932, rs676309, rs667897, rs662196, rs583791 or rs1562990 is present in the MS4A gene cluster locus; and (c) where SNP rs11136000 is present in the clusterin locus and rs3851179 is present in the PICALM locus; one of rs1408077, rs6701713 or rs3818361 is present in the CR1 locus; one of rs7561528 or rs744373 is present in the BIN1 locus; rs3764650 is present in the ABCA7 locus; and one of rs670139, rs610932, rs676309, rs667897, rs662196, rs583791 or rs1562990 is present in the MS4A gene cluster locus concluding that the individual from whom the sample has been extracted is likely to develop, or is suffering from, Alzheimer's disease. |
