发明名称 |
TDP-43 transgenic mouse model for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) |
摘要 |
<p>Non-human animal models for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) are disclosed. The invention relates to a transgenic mouse whose genome comprises a transgene operably linked to a neuronal specific promoter effective for an increased expression of the transgene in the brain of the mouse, in which the transgene comprises a nucleotide sequence encoding TAR DNA-binding protein 43 (TDP-43). The transgenic mouse exhibits reduced or impaired learning and memory capacity, and may further exhibits progressively impaired or reduced motor functions. Methods of using such animal models are also disclosed.</p> |
申请公布号 |
EP2258857(B1) |
申请公布日期 |
2015.04.29 |
申请号 |
EP20100164242 |
申请日期 |
2010.05.28 |
申请人 |
ACADEMIA SINICA |
发明人 |
SHEN, CHE-KUN JAMES;TSAI, KUEN-JER |
分类号 |
C12N15/85;A01K67/027;C12N5/079 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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