发明名称 CYCLOHEXANE-1,2'-NAPHTHALENE-1',2-IMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS
摘要 Cyclohexane-1,2′-naphthalene-1′,2″-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating A&bgr;-related pathologies such as Down's syndrome, &bgr;-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration, methods of therapy using such compounds, and pharmaceutical compositions containing such compounds.
申请公布号 EP2864314(A1) 申请公布日期 2015.04.29
申请号 EP20130731450 申请日期 2013.06.20
申请人 ASTRAZENECA AB 发明人 KARLSTRÖM, SOFIA;SANDBERG, LARS;SÖDERMAN, PETER;KOLMODIN, KARIN;ÖHBERG, LISELOTTE
分类号 C07D401/04;A61K31/4188;C07D491/107 主分类号 C07D401/04
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