| 发明名称 |
Non-wild-type organophosphorus acid anhydrolases for enzymatic decontamination |
| 摘要 |
Provided are non-wild-type organophosphorus acid anhydrolases that are capable of degrading (ethyl {2-[bis(propan-2-yl)amino]ethyl}sulfanyl) (methyl)phosphinate and other V-agents. Particular embodiments include an organophosphorus acid anhydrolase including an amino acid substitution at position 212. |
| 申请公布号 |
US9017982(B1) |
申请公布日期 |
2015.04.28 |
| 申请号 |
US201314109119 |
申请日期 |
2013.12.17 |
| 申请人 |
The United States of America as Represented by the Secretary of the Army |
发明人 |
Shah Saumil S.;Guelta Mark A.;Harvey Steven P. |
| 分类号 |
C12N9/18;A61K38/46;C12N9/16 |
主分类号 |
C12N9/18 |
| 代理机构 |
|
代理人 |
Biffoni Ulysses John |
| 主权项 |
1. A non-wild-type organophosphorus acid anhydrolase protein, comprising: a non-wild-type amino acid at sequence position 212, wherein said protein comprises the amino acid sequence of SEQ ID NO: 2. |
| 地址 |
Washington DC US |
