Coaxial needle atomizing system

摘要

An atomizing system tar generating an aerosol for inhalation research is disclosed. The atomizing system, in one embodiment, is capable of functioning efficiently at ultra-low liquid and low gas feed rates through the use of a 32 gauge feed line. This feed line reduces dead space in the atomizing system as well as the amount of highly toxic and/or expensive fluid needed to perform the research. An aerosol is generated in a consistent and repeatable manner by injecting fluid at a teed rate of 0.2-20 μl/min into a gas stream from a compressed gas source at a pressure of 30-60 psi. An adapter is used to connect a syringe containing the fluid to be tested to the 32 gauge feed line.

主权项

1. A system for performing inhalation research with aerosols, comprising:
a containment system further comprising a glove box; an atomizing system for generating an aerosol, the atomizing system further comprising:
a tee fitting haying a main bore and a secondary bore perpendicular to the main bore, the secondary bore coupled to a compressed gas source at a pressure of approximately 30-60 psi;a tube extending through the main bore of the tee fitting, wherein a first end of the tube adjacent to a first end of the main bore of the tee fitting is attached to a syringe and is capable of receiving a fluid compound from the syringe at a fee rate of 0.2-20 μl/min; anda needle attached to a second end of the main bore of the tee fitting, the needle receiving compressed gas from the secondary bore and the main bore of the tee fitting;wherein the tube extends through the tee fitting and the needle so that a second end of the tube extends slightly beyond the needle and fluid is injected from the end of the tube into the compressed gas flow from the annular opening between the tube and the needle; and equipment for performing tests on the aerosol; wherein the atomizing system and the equipment for performing tests are contained within the glove box.