Collagen fibrillar construction

摘要

Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.

主权项

1. A method of producing an organized array of collagen fibrils, the method comprising:
contacting a template with a still solution comprising collagen monomers in liquid crystalline phase; and neutralizing the solution in contact with the template, thereby inducing assembly of the collagen monomers into an organized array of collagen fibrils, wherein the template comprises one or more internal guidance structures, the assembly of the collagen monomers is into a pattern or direction defined by the guidance structures, and the organized array of collagen fibrils is about 100 μm to about 30 cm in length.