Sulfone compounds as 5-HT6 receptor ligands

摘要

The present invention relates to novel sulfone compounds as 5-HT6 receptor ligands of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them.;;The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them.;These compounds are useful in the treatment/prevention of various disorders that are related to 5-HT6 receptor functions.

主权项

1. A compound which is selected from the group consisting of:
N-[2-Methyl-5-(6-chloro-1H-indole-3-yl sulfonyl)phenyl]-N-(1-methyl piperidin-4-yl)amine; N-(1-Methyl piperidin-4-yl)-N-[3-(6-chloro-1H-indole-3-yl sulfonyl)phenyl]amine hydrochloride; N-(1-Methyl piperidin-4-yl)-N-[3-(5-fluoro-1H-indole-3-yl sulfonyl)phenyl]amine hydrochloride; N-(1-Methyl piperidin-4-yl)-N-[2-chloro-5-(6-chloro-1H-indole-3-yl sulfonyl)phenyl]amine hydrochloride; N-(1-Methyl piperidin-4-yl)-N-[2-methoxy-5-(1H-Indole-3-yl sulfonyl)phenyl]amine; N-(1-Methyl piperidin-4-yl)-N-[2-methoxy-5-(5-methoxy-1H-Indole-3-yl sulfonyl)phenyl]amine; N-(Piperidin-4-yl)-N-[2-methoxy-5-(5-methoxy-1H-Indole-3-yl sulfonyl)phenyl]amine; N-(Piperidin-4-yl)-N-[2-methoxy-5-(6-chloro-1H-Indole-3-yl sulfonyl)phenyl]amine; and N-(1-Methyl piperidin-4-yl)-N-[2-methoxy-5-(6-chloro-1H-Indole-3-yl sulfonyl)phenyl]amine.