发明名称 |
PREDICTING PATIENT RESPONSIVENESS TO IMMUNE CHECKPOINT INHIBITORS |
摘要 |
The invention is directed to a method of predicting clinical response of a patient to treatment of a cancer by an immune checkpoint pathway inhibitor, such as an anti-CTLA-4 or anti-PD-1 antibody binding compound. In one aspect the method comprises generating pre- and post-treatment clonotype profiles, determining a number of clonotypes that decrease in frequency between the first and second clonotype profiles, and predicting a lack of responsiveness in the patient to the treatment whenever the number of clonotypes that decrease in frequency is greater than a predetermined value. |
申请公布号 |
WO2015058159(A1) |
申请公布日期 |
2015.04.23 |
申请号 |
WO2014US61260 |
申请日期 |
2014.10.17 |
申请人 |
SEQUENTA, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
KLINGER, MARK;FAHAM, MALEK;MOORHEAD, MARTIN;FONG, LAWRENCE |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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