DRUG-CONJUGATES WITH A TARGETING MOLECULE AND TWO DIFFERENT DRUGS
摘要
<p>There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second drug conjugate with a different drug to a Lys residue on the targeting protein.</p>
申请公布号
WO2015057876(A1)
申请公布日期
2015.04.23
申请号
WO2014US60750
申请日期
2014.10.15
申请人
SORRENTO THERAPEUTICS INC.
发明人
MIAO, ZHENWEI;CHEN, GANG;ZHU, TONG;KHASANOV, ALISHER B.;HONG, YUFENG;CHUCHOLOWSKI, ALEXANDER;ZHAN, HONG