ELASTIN PRODUCING FIBROBLAST FORMULATIONS AND METHODS OF USING THE SAME

摘要

The present invention describes therapeutic compositions comprising fibroblasts that have been stimulated to increase expression of extracellular matrix components or elastin, or to produce enhanced elastogenesis or the appearance thereof at a site of administration. The therapeutic fibroblast formulations can be prepared using a variety of elastogenic agents, including digests of mammalian elastin, chemically digested plant extracts comprising elastin-like peptides, and synthetic elastogenic peptides. The invention further comprises cosmetic and pharmaceutical treatment methods using the therapeutic fibroblast compositions of the invention.

主权项

1. A therapeutic composition for stimulating elastogenesis or the appearance thereof comprising a therapeutically effective amount of a population of cultured dermal fibroblasts, wherein said population of cultured dermal fibroblasts is pretreated with an elastogenic composition.