CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF
摘要
Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (CAR-ECs). The switches generally comprise a chimeric antigen receptor-interacting domain (CAR-ID) and a target interacting domain (TID). The switch may furthercomprise a linker. Further disclosed herein are methods of using the switches for the treatment of one or more conditions or diseases in a subject in need thereof.
申请公布号
CA2926698(A1)
申请公布日期
2015.04.23
申请号
CA20142926698
申请日期
2014.10.15
申请人
THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH;THE SCRIPPS RESEARCH INSTITUTE
发明人
KIM, CHANHYUK;YOUNG, TRAVIS;CAO, YU;MA, JENNIFER;KIM, MINSOO;PINKERTON, STEPHANIE;SCHULTZ, PETER G.