发明名称 |
POLYNUCLEOTIDES ENCODING RODENT ANTIBODIES WITH HUMAN IDIOTYPES AND ANIMALS COMPRISING SAME |
摘要 |
The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides. |
申请公布号 |
US2015113668(A1) |
申请公布日期 |
2015.04.23 |
申请号 |
US201414517755 |
申请日期 |
2014.10.17 |
申请人 |
OMT, Inc. |
发明人 |
BRUGGEMANN Marianne;BUELOW Roland;OSBORN Michael J.;MA Biao |
分类号 |
C07K16/00;A01K67/027 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
1. A transgenic rodent, the rodent comprising in its germline a heavy chain immunoglobulin locus comprising human unrearranged heavy chain variable region gene segments linked to DNA encoding a rodent heavy chain constant region, wherein the heavy chain immunoglobulin locus does not comprise a human immunoglobulin constant region gene, and wherein the rodent is a mouse or a rat. |
地址 |
Palo Alto CA US |