摘要 |
<p>An in-depth study is performed on selaginella pulvinata extractives in the present invention, and it is found that the selaginella pulvinata extractives have a significant anti-inflammatory activity. Multiple column chromatography separation technologies and a semi-preparation high-performance liquid chromatography separation method are used to extract and separate a class of compounds (DZJB1-6) with a 9,9-diphenyl-1-(phenylethynyl)-9H-fluorene new skeleton structure, named as selaginpulvilinsA-F (structural formula (I)). The six compounds extracted and separated from selaginella pulvinata are subjected to structural modification, and then a series of compounds are obtained. These compounds can significantly inhibit the activity of type-4 phosphodiesterase (PDE4), and can be used for preparing PDE4 inhibitors, and treating asthma, chronic obstructive pneumonia, inflammations, and the like. According to the present invention, a new structure is provided for the development of PDE4 inhibitors.</p> |