发明名称 |
FIXED DOSAGE REGIMENS FOR ANTI-TYPE I INTERFERON RECEPTOR (IFNAR) ANTIBODIES |
摘要 |
The disclosure provides methods for treating a subject having a type I IFN-mediated disease or disorder comprising administration of a fixed does of an anti-interferon alpha receptor antibody. The disclosure also provides methods for suppressing a type I interferon (IFN) gene signature (GS) in a subject. In addition, the disclosure provides methods of prognosing or monitoring disease progression in a subject having a type I IFN-mediated disease or disorder, methods of predicting a dosage regimen, methods of identifying a candidate therapeutic agent, methods of identifying a patient as a candidate for a therapeutic agent, and methods of designating a personalized therapy. |
申请公布号 |
EP2861621(A1) |
申请公布日期 |
2015.04.22 |
申请号 |
EP20130803921 |
申请日期 |
2013.06.12 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
HIGGS, BRANDON;YAO, YIHONG;WANG, BING;ROSKOS, LORIN;CHANG, LINDA |
分类号 |
C07K16/24;A61K39/395;C07K16/00 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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