Method of stabilizing antibody and stabilized solution-type antibody preparation

摘要

The present invention provides a method of suppressing the formation of a soluble association of an antibody in a solution; a method of suppressing the formation of a chemically degraded product of an antibody in a solution; and a method of stabilizing an antibody in a solution. The present invention also provides a solution-type antibody preparation in which the formation of a soluble association is suppressed; a solution-type antibody preparation in which the formation of a chemically degraded product is suppressed; a solution-type antibody preparation in which the formation of a soluble association, the formation of a chemically degraded product and the formation of an insoluble aggregate are suppressed; an agent for suppressing the formation of a soluble association of an antibody; an agent for suppressing the formation of a chemically degraded product of an antibody; and a stabilizing agent for an antibody.

主权项

1. A method for producing an antibody solution in which the formation of soluble dimers and trimers of antibody is inhibited, wherein said method comprises the step of:
suppressing the formation of soluble dimers and trimers of an antibody by combining, in a solution, 10 to 30 mg/ml glycine, 0.1 to 50 mmol/L citric acid, and the antibody, to produce an antibody solution in which the formation of soluble dimers and trimers of the antibody is inhibited.