Quantifying cell death

摘要

The invention relates to methods of diagnosis, particularly methods of staging and diagnosing neurodegenerative diseases using images of cell death in the eye.

主权项

1. A method of determining the stage of a disease or diagnosing a disease, comprising:
generating an in vivo image of apoptosing cells in a subject's eye, wherein the subject has been administered a labeled apoptotic marker, and counting the number of apoptosing cells or analyzing a pattern of distribution of apoptosing cells in the image, the method further comprising comparing the number of apoptosing cells or pattern of distribution of apoptosing cells with a previously generated in vivo image of apoptosing cells in the subject's eye.