| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to field of organic chemistry, namely to method of obtaining N,N'-di(1-adamantyl)bispidin-9-ones, where R=R'=methyl (1a), R=R'=ethyl (1b), R=R'=propyl (1c), R=methyl and R'=1-adamantylaminomethyl (2), R=R'=1-adamantylaminomethyl (3). Method is realised by two-stage condensation, at the first stage condensed is 1-aminoadamantane with formaldehyde, at the second stage formed product is condensed with ketones in the same reactor with heating in butanol or other alcohols. Obtained products are extracted after condensing reaction mass under vacuum with hot toluene and re-crystallised from toluene.EFFECT: N,N'-di(1-adamantyl)bispidin-9-ones, which can be used as substances for medications and as initial substances for obtaining novel derivatives of N,N'-di(1-adamantyl)bispidine.5 ex |
