发明名称 |
GABAB RECEPTOR NEGATIVE ALLOSTERIC MODULATOR AND MEDICAL USE THEREOF |
摘要 |
<p>The present invention relates to the field of pharmaceutical chemistry. In particular, the present invention relates to a γ-aminobutyric acid type-B receptor (Gamma Aminobutyric Acid B Receptor, referred to as a GABABR or GABAB receptor for short) ligand molecule and a medicinal use thereof, wherein the ligand molecule has the structure of formula I. The ligand molecule which the present invention relates to is a GABAB receptor negative allosteric modulator, can non-competitively inhibit GABAB receptor agonist-induced activation of the receptor, and can be used to prepare drugs for the treatment of GABAB receptor hyperexcitability-related diseases, wherein the diseases comprise epilepsy, anxiety, depression or low cognitive ability caused by nerve damage, and so on.</p> |
申请公布号 |
WO2015051760(A1) |
申请公布日期 |
2015.04.16 |
申请号 |
WO2014CN88328 |
申请日期 |
2014.10.10 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY |
发明人 |
NAN, FAJUN;LIU, JIANFENG;CHEN, LINHAI;SUN, BING |
分类号 |
C07C39/00;A61K31/00;C07C49/04;C07C49/20 |
主分类号 |
C07C39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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