发明名称 |
SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS |
摘要 |
Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. |
申请公布号 |
EP2768833(A4) |
申请公布日期 |
2015.04.15 |
申请号 |
EP20120840924 |
申请日期 |
2012.10.19 |
申请人 |
SIRTRIS PHARMACEUTICALS, INC.;GLAXOSMITHKLINE LLC |
发明人 |
BLUM, CHARLES, A.;DISCH, JEREMY, S.;SPRINGER, STEPHANIE, K. |
分类号 |
C07D487/04;A61K31/437;A61P3/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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