发明名称 |
METHOD OF IN VITRO DIFFERENTIATION OF MOTOR NEURON PROGENITORS (MNPS) FROM HUMAN INDUCED PLURIPOTENT STEM CELLS AND CRYOPRESERVATION OF MNPS |
摘要 |
Methods are disclosed for the initiation and differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) into motor neuron progenitor cells (MNPs). Methods are also disclosed for the cryopreservation of MNPs. The methods particularly relate to the simple, efficient, scalable, and reproducible generation, and subsequent frozen maintenance, of MNPs for downstream therapeutic applications. The methods can be used for the production of MNPs from various lines of hESCs and iPSCs. |
申请公布号 |
EP2858581(A2) |
申请公布日期 |
2015.04.15 |
申请号 |
EP20130803543 |
申请日期 |
2013.06.11 |
申请人 |
LONZA WALKERSVILLE, INC. |
发明人 |
YANG, FAN;TRAN, HUAN;FELLNER, THOMAS |
分类号 |
C12N5/02;A01N1/02;A61K35/30;C12N5/071;C12N5/0793 |
主分类号 |
C12N5/02 |
代理机构 |
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代理人 |
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地址 |
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