发明名称 |
Contiguous overlapping peptides for treatment of ragweed pollen allergy |
摘要 |
Contiguous overlapping peptides (COPs) for the treatment of allergic patients by Specific Immunotherapy (SIT) are provided from the sequence of the major allergen of ragweed pollen Amb a 1. Such peptides while providing all potential T cell epitopes are devoid of the three-dimensional structure of the original allergen, therefore reducing their ability to bind IgE. |
申请公布号 |
US9005627(B2) |
申请公布日期 |
2015.04.14 |
申请号 |
US201213533656 |
申请日期 |
2012.06.26 |
申请人 |
Anergis S.A. |
发明人 |
Reymond Christophe;Spertini Francois |
分类号 |
A61K38/00;A61K38/04;A61K39/00;A61K39/35;A61K39/36;A61K39/38;C07K14/415 |
主分类号 |
A61K38/00 |
代理机构 |
Marshall, Gerstein & Borun LLP |
代理人 |
Marshall, Gerstein & Borun LLP |
主权项 |
1. A composition comprising a plurality of peptide fragments comprising a first polypeptide consisting of the sequence from amino acids 43-53 to amino acids 96-121 of SEQ ID NO: 12 wherein the reactivity of said peptide to IgE antibodies of subjects who are allergic to ragweed pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to ragweed pollen is retained,
a second peptide consisting of the sequence from amino acids 96-121 to amino acids 111-147 of SEQ ID NO: 12 wherein the reactivity of said peptide to IgE antibodies of subjects who are allergic to ragweed pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to ragweed pollen is retained, a third peptide consisting of the sequence from amino acids 111-147 to amino acid 168-180 of SEQ ID NO: 12 wherein the reactivity of said peptide to IgE antibodies of subjects who are allergic to ragweed pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to ragweed pollen is retained, a fourth peptide consisting of the sequence from amino acid 168-190 to amino acids 220-251 of SEQ ID NO: 12 wherein the reactivity of said peptide to IgE antibodies of subjects who are allergic to ragweed pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to ragweed pollen is retained, a fifth peptide consisting of the sequence from amino acids 190-241 to amino acids 251-269 of SEQ ID NO: 12 wherein the reactivity of said peptide to IgE antibodies of subjects who are allergic to ragweed pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to ragweed pollen is retained, a sixth peptide consisting of the sequence from amino acids 241-269 to amino acids 309-329 of SEQ ID NO: 12 wherein the reactivity of said peptide to IgE antibodies of subjects who are allergic to ragweed pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to ragweed pollen is retained and a seventh peptide consisting of the sequence from amino acids 309-329 to amino acids 384-396 of SEQ ID NO: 12 wherein the reactivity of said peptide to IgE antibodies of subjects who are allergic to ragweed pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to ragweed pollen is retained. |
地址 |
Epalinges CH |