Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases

摘要

The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun amino terminal kinase, JNK inhibitor sequences, chimeric peptides, or of nucleic acids encoding same as well as pharmaceutical compositions containing same, for the treatment of various diseases or disorders strongly related to JNK signaling, wherein these diseases or disorders are selected from autoimmune disorders, cardiovascular diseases, cancerous diseases, diabetes, including diabetes type 1 or type 2, inflammatory diseases, hair loss, including Alopecia areata, diseases of the lung, neuronal or neurodegenerative diseases, diseases of the liver, diseases of the spine, diseases of the uterus, viral infectious diseases and depressive disorders.

主权项

1. A method of treating a disease or disorder, the method comprising administering a pharmaceutical composition to the subject in need of treatment thereof, the composition comprising a c-Jun amino terminal kinase (JNK) inhibitor sequence consisting of (i) SEQ ID NO: 2, or (ii) a chimeric peptide consisting of a first domain and a second domain linked by a covalent bond without any linker sequence or via a linker sequence comprising the covalent bond, the first domain comprising a trafficking sequence, and the second domain consisting of a JNK inhibitor sequence according to SEQ ID NO: 2, wherein the first domain is linked to the C-terminal end of the second domain,
wherein the disease or disorder is selected from the group consisting of chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis.