发明名称 |
Anti-bacterial and mineralizing calcium phosphate compositions |
摘要 |
The present invention provides compositions including saturated calcium phosphate (sCaP) solutions, that may be prepared from mixtures of calcium deficient apatite and one or more of sodium fluoride and zinc chloride, or F or Zn ions. The solutions may be prepared from mixtures of calcium compounds and one or more of sodium or potassium phosphates, sodium or potassium fluoride and zinc salts with, for instance, either phosphoric or hydrochloric acids. Such compositions may be useful for increasing occlusion of dentin tubules, decreasing bacterial attachment to dentin tubules, decreasing bacterial growth or colonization on tooth surfaces such as enamel and dentin surfaces including on dentin tubules, increasing resistance to acid dissolution, inhibiting dental caries formation and progression and tooth decay and inhibiting development of tooth hypersensitivity. |
申请公布号 |
US9005587(B2) |
申请公布日期 |
2015.04.14 |
申请号 |
US201213433794 |
申请日期 |
2012.03.29 |
申请人 |
New York University |
发明人 |
LeGeros Racquel Z.;Gu Haijing;Mijares Dindo;Saxena Deepak;Bodepudi Sudharani |
分类号 |
A61Q11/00;A61K8/21;A61K8/27;A61K8/24;A61K6/033;A61K6/04;A61K6/00 |
主分类号 |
A61Q11/00 |
代理机构 |
Klauber & Jackson LLC |
代理人 |
Klauber & Jackson LLC |
主权项 |
1. A method for increasing or promoting occlusion of dentin tubules on the surface of a tooth comprising providing a composition including a saturated calcium phosphate (sCaP) solution supersaturated with both F- and Zn-substituted calcium phosphates and having a pH of about 5.0 to 7.5. |
地址 |
New York NY US |