Direct measurements of nanoparticles and virus by virus mass spectrometry

摘要

Apparatus and methods for performing mass spectrometry of a nanoparticle or virus analyte. Apparatus may include a laser desorption plate, a mass analyzer configured to measure mass over the range of m/z from 105 to 1010, an electrical shield surrounding the mass analyzer, and a charge sensitive detector, wherein the laser firing is phase lock synchronized with the applied radiofrequency voltages.

主权项

1. An apparatus for mass spectrometry comprising:
a desorption plate; a laser for firing a beam to impinge upon the desorption plate; a mass analyzer for measuring mass over the range of m/z from 105 to 1010 using applied trapping RF and axial RF voltages, wherein the mass analyzer is a quadrupole ion trap having a ring electrode and first and second end cap electrodes, wherein the ring electrode is spaced apart by a gap from the first end cap electrode, and wherein the desorption plate is adjacent to the gap; an electrical shield surrounding the mass analyzer; a charge sensitive detector, wherein the electrical shield electrically isolates the mass analyzer from the charge sensitive detector; and a synchronizer for phase locking the laser firing to the applied trapping RF.