| 发明名称 | 23-yne-vitamin D<sub>3 </sub>derivative | ||
| 摘要 | To provide a novel vitamin D3 derivative useful as a therapeutic agent for osteoporosis.;Provided is a vitamin D3 derivative represented by the following formula (1) or a medicinally acceptable solvate thereof:;wherein R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alkylcarbonyloxyalkyl group with each alkyl having 1 to 6 carbon atoms, or an arylcarbonyloxyalkyl group with the aryl having 6 to 10 carbon atoms and the alkyl having 1 to 6 carbon atoms; R2 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or, together with the other R2 and the carbon atom to which they are bound to, may form a cyclic alkyl group having 3 to 6 carbon atoms; R3 represents an alkyl group having 1 to 6 carbon atoms or, together with the other R3 and the carbon atom to which they are bound to, may form a cyclic alkyl group having 3 to 6 carbon atoms; X represents an oxygen atom or a methylene group; and n represents an integer of 1 or 2. | ||
| 申请公布号 | US9006220(B2) | 申请公布日期 | 2015.04.14 |
| 申请号 | US201113880637 | 申请日期 | 2011.10.24 |
| 申请人 | Teijin Pharma Limited | 发明人 | Saito Hiroshi;Komiyama Masato;Ochiai Eiji;Takagi Kenichiro;Chida Takayuki;Fujita Mariko;Imaizumi Keiichiro;Kaneko Toshiyuki |
| 分类号 | C07C401/00;C07F7/18 | 主分类号 | C07C401/00 |
| 代理机构 | Sughrue Mion, PLLC | 代理人 | Sughrue Mion, PLLC |
| 主权项 | 1. A compound represented by the following formula (1): wherein R1 represents a hydrogen atom, alkyl group having 1 to 6 carbon atoms, an alkylcarbonyloxyalkyl group with each alkyl having 1 to 6 carbon atoms, or an arylcarbonyloxyalkyl group with the aryl having 6 to 10 carbon atoms and the alkyl having 1 to 6 carbon atoms; R2 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or, together with the other R2 and the carbon atom to which they are bound to, may form a cyclic alkyl group having 3 to 6 carbon atoms; R3 represents an alkyl group having 1 to 6 carbon atoms or, together with the other R3 and the carbon atom to which they are bound to, may form a cyclic alkyl group having 3 to 6 carbon atoms; X represents an oxygen atom or a methylene group; and n represents an integer of 1 or 2. | ||
| 地址 | Tokyo JP | ||