PEPTINOGLYCANE HYDROLASE, EXPRESSION PLASMID, CONTAINING PEPTIDOGLYCANE HYDROLASE-CODING DNA FRAGMENT, BACTERIUM-PRODUCER AND METHOD OF MICROBIOLOGICAL SYNTHESIS OF PEPTIDOGLYCANE HYDROLASE

摘要

FIELD: chemistry.SUBSTANCE: group of inventions relates to biotechnology, in particular to peptydoglycane hydrolase biosynthesis, and represents a protein with the peptydoglycane hydrolase activity, a plasmid, containing a peptydoglycane hydrolase-coding fragment, a bacterium-producer, a method of microbiological peptydoglycane hydrolase synthesis, as well as a pharmaceutical composition, containing the obtained peptydoglycane hydrolase, for the therapy of diseases, caused by Gram-negative microflora.EFFECT: elaborated method of microbiological synthesis makes it possible to obtain bacteriophage S-394 peptydoglycane hydrolase in an effective way.22 cl, 2 dwg, 9 ex