| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to new compounds of formula I, wherein Rand Rare identical or different and specified in an alkyl or alkenyl hydrocarbon chain; the Rgroup values split by lipase are specified in the patient claim. Rand Rare independently hydrogen or C-Calkyl; Rrepresents hydrogen or C-Calkyl; and Rand Rare independently hydrogen or C-Calkyl. The invention also refers to using compounds of formulas,which are introduced into the mammalian biological system and increase the cell concentrations of specific sn-2 substituted ethanolamine-plasmalogens.EFFECT: compounds are applicable in treating or preventing the age-related disorders associated with high membrane cholesterol, high amyloids and low plasmalogens, such as neurodegeneration, cognitive disorder, dementia, cancer, osteoporosis, bipolar disorder and vascular diseases.11 cl, 18 dwg, 7 ex |
