| 发明名称 |
CANCER TREATMENT AND MONITORING METHODS USING OX40 AGONISTS |
| 摘要 |
OX40 is a potent immune stimulating target. Provided herein are methods for the treatment of cancer patients using (3X40 agonists methods to predict clinical outcome of the treatment by correlation of the treatment and an increase in OX40-induced T cell proliferation. |
| 申请公布号 |
US2015098942(A1) |
申请公布日期 |
2015.04.09 |
| 申请号 |
US201214376998 |
申请日期 |
2012.02.06 |
| 申请人 |
Curti Brendan;Kovacsovics-Bankowski Magdalena;Walker Ed;Walker Josh;Weinberg Andy |
发明人 |
Curti Brendan;Kovacsovics-Bankowski Magdalena;Walker Ed;Walker Josh;Weinberg Andy |
| 分类号 |
C07K16/28;G01N33/569;C07K14/715 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating cancer, comprising administering to a patient in need of treatment an effective amount of an OX40 agonist, wherein the administration increases the level of Ki-67 expression in T-lymphocytes of the patient, or a subpopulation thereof over a corresponding baseline level, and can stimulate T-lymphocyte activity against cancer cells in the patient. |
| 地址 |
Portland OR US |
