| 发明名称 |
POLYNUCLEOTIDES ENCODING ANTIBODIES |
| 摘要 |
The present invention relates to antagonizing the activity of IL-17A, IL-17F and IL-23 using bispecific antibodies that comprise a binding entity that is cross-reactive for IL-17A and IL-17F and a binding entity that binds IL-23p19. The present invention relates to novel bispecific antibody formats and methods of using the same. |
| 申请公布号 |
US2015099278(A1) |
申请公布日期 |
2015.04.09 |
| 申请号 |
US201414576278 |
申请日期 |
2014.12.19 |
| 申请人 |
Bristol-Myers Squibb Company |
发明人 |
Stevens Brenda L.;Witte Alison;Rixon Mark W.;Cardarelli Josephine M.;Kempe Thomas D.;Presnell Scott R.;Srinivasan Mohan;Wong Susan C.;Chen Guodong;Wei Hui;Krystek Stanley R.;Schneeweis Lumelle A.;Sheppard Paul O.;Chakraborty Indrani |
| 分类号 |
C07K16/24 |
主分类号 |
C07K16/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated nucleic acid molecule encoding a bispecific antibody comprising an IL-17A/F binding entity and an IL-23 binding entity, wherein the IL-23 binding entity comprises two pairs of immunoglobulin chains, each pair having one light and one heavy chain, which light chain variable domain comprises a CDR1 having the amino acid sequence of SEQ ID NO:22, a CDR2 having the amino acid sequence of SEQ ID NO:23, and a CDR3 having the amino acid sequence of SEQ ID NO:24, and heavy chain variable domain comprises a CDR1 having the amino acid sequence of SEQ ID NO:19, a CDR2 having the amino acid sequence of SEQ ID NO:20, and a CDR3 having the amino acid sequence of SEQ ID NO:21, and wherein the IL-17A/F binding entity comprises two Fab fragments which are linked to the C-terminus of the heavy chain of the IL-23 binding entity. |
| 地址 |
Princeton NJ US |
