PROTEIN CONSTRUCTS DESIGNED FOR TARGETING AND LYSIS OF CELLS

摘要

The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.

主权项

1. A method of killing undesired target cells in a patient, the method comprising administering to a patient in need thereof with an effective amount of a multimeric protein construct including a multimerizing scaffold bearing (i) at least one targeting moiety that is capable of binding to a target cell, and (ii) at least two effector immunogenic moieties that are non-toxic by themselves, wherein the multimerizing scaffold is a C4BP protein or a multimerizing fragment thereof and the effector moiety is fragment C of tetanus toxin (TTFgC).