| 发明名称 |
BLOOD-BASED GENE EXPRESSION SIGNATURES IN LUNG CANCER |
| 摘要 |
The invention pertains to a method for diagnosing or detecting lung cancer in human subjects based on ribonucleic acid (RNA) expression, in particular based on RNA from blood. The invention discloses 361 genes which are differentially expressed in blood from lung cancer patients and discloses that at least 4 of the mRNAs must be determined in order to have an AUC of at least 0.8. |
| 申请公布号 |
US2015099643(A1) |
申请公布日期 |
2015.04.09 |
| 申请号 |
US201414328365 |
申请日期 |
2014.07.10 |
| 申请人 |
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN ;UNIVERSITAT ZU KOLN |
发明人 |
HOFMANN Andrea;SCHULTZE Joachim L.;WOLF Jurgen;STARATSCHEK-JOX Andrea;ZANDER Thomas |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for the detection of lung cancer in a human subject based on RNA from a blood sample obtained from said subject, comprising:
Measuring the abundance of at least 4 RNAs in the sample, that are chosen from the RNAs listed in table 3 or in table 3b, and Concluding based on the measured abundance whether the subject has lung cancer. |
| 地址 |
Bonn DE |
