摘要 |
The present invention relates to a polypeptide or polypeptide complex, comprising at least one non-ribosomal peptide synthesis (NRPS) amino acid module functionally connected to at least one pigment module. The present invention further relates to a labeled oligopeptide comprising a non-naturally attached NRPS pigment or/and polyketide pigment, to a polynucleotide encoding a fusion polypeptide, a vector, preferably an expression vector, comprising the polynucleotide of the present invention and to a host cell comprising the polypeptide or polypeptide complex and/or the polynucleotide, and/or the vector according to the present invention. Moreover, the present invention relates to in vitro and in vivo method of producing a labeled oligopeptide, as well as to methods of optimizing the same. |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM;RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG |
发明人 |
EILS, ROLAND;DI VENTURA, BARBARA;ADLUNG, LORENZ;GENREITH, KATHARINA;HEINEMANN, TIM;MEYER, HANNAH;NIOPEK, DOMINIK;GEORGI, FANNY;BEER, RALF;CHRISTIANSEN, TANIA CHRISTINA;HERBST, KONRAD;IGNATIADIS, NIKOLAOS;KATS, ILIA;KURZAWA, NILS;MEICHSNER, JOHANNA;RABE, SOPHIE;RIEDEL, ANJA;SACHS, JOSHUA;SCHESSNER, JULIA PATRICIA;SCHMIDT, FLORIAN;WALCH, PHILIPP DARIUS KONSTANTIN |