SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE

摘要

A microfluidic device for increasing convective clearance of particles from a fluid is provided. A network of first channels can be separated from a network of second channels by a first membrane. The network of first channels can also be separated from a network of third channels by a second membrane. Fluid containing an analyte can be introduced in the network of first channels. Infusate can be introduced into the network of second channels, and waste-collecting fluid can be introduced into the network of third channels. A pressure gradient can be applied in a direction perpendicular to the direction of fluid flow in the network of first channels, such that the analyte is transported from the network of first channels into the network of third channels through the second membrane.

主权项

1. A method for filtering a first liquid containing an analyte to provide a filtered liquid containing less analyte than the first liquid, the method comprising the steps of:
introducing the first liquid into an inlet of one or more First Channels; introducing infusate into at least one Second Channel complementary to the one or more First Channels, such that at least some of the infusate flows from the at least one Second Channel through a first membrane and into the one or more First Channels; introducing waste-collecting fluid into at least one Third Channel complementary to the one or more First Channels such that at least some of the analyte in the first liquid is transported through a second membrane into the at least one Third Channel; and collecting the filtered solution from an outlet of one or more of the First Channels.