| 摘要 |
PROBLEM TO BE SOLVED: To provide a monomer useful in preparing therapeutic compounds.SOLUTION: The invention relates to a monomer including a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element which has a molecular weight less than 500 dalton. The linker element is connected, directly or indirectly through a connector, to the diversity element, and is capable of forming a reversible covalent bond or non-covalent interaction with a binding partner linker element on other monomer with a dissociation constant of less than 300 μM with or without a co-factor under physiological conditions. The linker element is an aliphatic compound with an α-, &bgr;-, or γ-hydroxy group to a carbonyl group, where the linker element and a binding partner thereof, when bound together, form a 6 or 8 member di-hemiacetal or di-hemiketal rings. The linker element is selected from the specific ones. |
