| 摘要 |
<p>The present invention relates to a composition for inhibiting diabetic renal fibrosis and renal tubular scleroma containing chrysin as an active ingredient. According to the present invention, a human renal proximal tubular epithelial cell (RPTEC), directly related to renal fibrosis by renal tubular fibrosis caused by complication of diabetes, is exposed to high blood sugar, is treated with chrysin as an active ingredient, and is cultured for three days to obtain the composition. The composition: inhibits activity of a connective tissue growth factor (CTGF); reduces generation of a fourth type collagen; reduces expression N-cadherin, a biomarker for protein related to an epithelial-mesenchymal transition (EMT); increases expression of E-cadherin, cell adhesion protein inhibiting EMT; and thus alleviates renal tubular fibrosis and renal fibrosis caused by chronic diabetes.</p> |
