METHODS FOR PREDICTING THE RESPONSIVENESS OF A PATIENT AFFECTED WITH CHRONIC MYELOID LEUKEMIA (CML) TO A TREATMENT WITH A TYROSINE KINASE INHIBITOR (TKI)

摘要

The invention relates to a method for predicting the responsiveness of a patient affected by a chronic myeloid leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) to a treatment with a tyrosine kinase inhibitor (TKI) comprising the following steps of: a) obtaining a sample from the patient; b) contacting said sample with a TKI; and c) determining the DNA repair capacity of said sample; wherein the responsiveness is predicted when a DNA repair capacity is observed.