| 摘要 |
The present invention relates to a viral vector for silencing a gene specifically in astrocytes comprising:—an astrocyte-specific viral envelope protein,—a first nucleic acid sequence encoding a transcription activator and at least one target sequence of a neuron-specific miR under the control of an astrocyte-specific promoter, and—a second nucleic acid sequence encoding a RNA for silencing the gene under the control of a promoter inducible by the transcription activator. |
