Method for in vitro investigating mitochondrial dna levels in a biological sample, kits and uses thereof

摘要

The invention relates to an in vitro method for investigating the level of mtDNA in a biological sample removed from a patient susceptible of suffering from a gastric cancer condition or susceptible of suffering of condition(s) susceptible to evolve in a gastric cancer condition by pooling said biological sample into categories, upon determination of the level of mtDNA in said biological sample. The invention also relates to a method for in vitro monitoring or diagnosing the health status of a patient susceptible of suffering from a gastric cancer condition or suffering from a gastric cancer condition or susceptible of suffering of condition(s) susceptible to evolve in a gastric cancer condition, comprising a step of measuring, in parallel to the investigation of the level of mtDNA, the level of any one of the following parameters: cytokine IL-8, platelet count (PLT) and/or mean platelet volume (MPV) and/or percentage of large platelets (LPLT), inflammatory markers such as IL-6 and/or IL-23, or any combination of these parameters, and concluding about the health status of the tested patient. The invention also relates to kit(s) suitable for carrying out the method(s) of the invention and their use.